The clinical efficacy of oral levodopa methyl ester solution in reversing afternoon "off" periods in Parkinson's disease

Clin Neuropharmacol. 1991 Jun;14(3):241-4. doi: 10.1097/00002826-199106000-00007.


We compared the efficacy of a single dose of an oral solution of levodopa methyl ester (ME) to that of standard levodopa, in the form of a single dose of Madopar, in reversing afternoon "off" periods in 12 patients with Parkinson's disease (PD). The highly soluble ME solution led to a significantly more rapid reversal of "off" periods. This preparation may therefore convey a clinical advantage in patients experiencing motor fluctuations whilst taking multiple daily dosages of levodopa, particularly in those with long or highly variable latency to the next "on" period.

MeSH terms

  • Administration, Oral
  • Aged
  • Benserazide / administration & dosage*
  • Benserazide / therapeutic use
  • Drug Combinations
  • Humans
  • Levodopa / administration & dosage*
  • Levodopa / analogs & derivatives*
  • Levodopa / therapeutic use
  • Middle Aged
  • Parkinson Disease / drug therapy*


  • Drug Combinations
  • benserazide, levodopa drug combination
  • Levodopa
  • Benserazide
  • levodopa methyl ester