Association of depression with antihypertensive medication adherence in older adults: cross-sectional and longitudinal findings from CoSMO

Ann Behav Med. 2010 Dec;40(3):248-57. doi: 10.1007/s12160-010-9217-1.

Abstract

Background: Little is known about the associations between depressive symptoms, social support and antihypertensive medication adherence in older adults.

Purpose: We evaluated the cross-sectional and longitudinal associations between depressive symptoms, social support and antihypertensive medication adherence in a large cohort of older adults.

Methods: A cohort of 2,180 older adults with hypertension was administered questionnaires, which included the Center for Epidemiologic Studies-Depression Scale, the Medical Outcomes Study Social Support Index, and the hypertension-specific Morisky Medication Adherence Scale at baseline and 1 year later.

Results: Overall, 14.1% of participants had low medication adherence, 13.0% had depressive symptoms, and 33.9% had low social support. After multivariable adjustment, the odds ratios that participants with depressive symptoms and low social support would have low medication adherence were 1.96 (95% confidence interval (CI) 1.43, 2.70) and 1.27 (95% CI 0.98, 1.65), respectively, at baseline and 1.87 (95% CI 1.32, 2.66) and 1.30 (95% CI 0.98, 1.72), respectively, at 1 year follow-up.

Conclusion: Depressive symptoms may be an important modifiable barrier to antihypertensive medication adherence in older adults.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / adverse effects*
  • Cross-Sectional Studies
  • Depression / etiology*
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Longitudinal Studies
  • Male
  • Medication Adherence*
  • Social Support*
  • Surveys and Questionnaires

Substances

  • Antihypertensive Agents