On the repair of thymine and thymidine bromohydrins: a possible new model for the damage and repair of nucleic acids

Chem Pharm Bull (Tokyo). 1991 Mar;39(3):612-5. doi: 10.1248/cpb.39.612.


Bromohydrins (2, 3, 4, and 5), oxidatively damaged products of thymine bases, were repaired on exposure to sunlight, heat, and/or some reagents to regenerate the thymine bases. A radical mechanism is proposed for the repair reaction with sunlight and heat. A hypothesis concerning the biological significance of thymidine in deoxyribonucleic acid is presented.

MeSH terms

  • DNA Damage / physiology*
  • DNA Repair / physiology*
  • Models, Chemical
  • Thymidine / analogs & derivatives*
  • Thymidine / chemistry
  • Thymine / analogs & derivatives*
  • Thymine / chemistry


  • thymidine bromohydrin
  • thymine bromohydrin
  • Thymine
  • Thymidine