Subclinical coronary artery disease in Asian rheumatoid arthritis patients who were in remission: a pilot study

Int J Rheum Dis. 2010 Aug;13(3):223-9. doi: 10.1111/j.1756-185X.2010.01533.x.


Introduction: Rheumatoid arthritis (RA) patients who have active disease with longer disease duration have been reported to have increased risk of cardiovascular events compared to the normal population.

Objective: The primary aim of our study is to ascertain the prevalence of significant asymptomatic coronary artery disease (CAD) in Asian RA patients who are in remission using multi-detector computed tomography (MDCT). The secondary aims of our study are the usage of pulse wave velocity and the biomarkers N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-senstivity C-reactive protein (hs-CRP) to detect subclinical atherosclerosis in RA patients.

Methods: We performed a comparative cross-sectional study of 47 RA patients who were in remission with a control group of non-RA patients with a history of atypical chest pain in Sarawak General Hospital from November 2008 to February 2009. All patients underwent 64-slice MDCT, assessment of arterial stiffness using the SphygmoCor test and blood analysis for NT-proBNP and hsCRP.

Results: There were 94 patients in our study with a mean age of 50 +/- 8.8 years. The RA and control patients in each group were matched in terms of traditional CV risk factors. Our RA patients had a median disease duration of 3 years (IQR 5.5). MDCT showed evidence of CAD in nine (19.1%) RA patients and three (6.4%) control patients (P = 0.06). There was no significant association between pulse wave velocity (PWV) and presence of CAD in our RA group. There was no significant correlation between PWV with levels of proBNP or hsCRP in our RA patients.

Conclusions: In our current pilot study with the limitation of small sample size, RA was not associated with an increased risk of CAD in our RA patients who were in remission. Larger studies of CAD in Asian RA patients are needed to confirm our current finding.

MeSH terms

  • Adult
  • Arteries / physiopathology
  • Arthritis, Rheumatoid / ethnology*
  • Arthritis, Rheumatoid / therapy
  • Asian People / statistics & numerical data*
  • Asymptomatic Diseases
  • Biomarkers / blood
  • C-Reactive Protein / analysis
  • Case-Control Studies
  • Chi-Square Distribution
  • Coronary Angiography / methods
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / ethnology*
  • Cross-Sectional Studies
  • Elasticity
  • Female
  • Humans
  • Malaysia / epidemiology
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain / blood
  • Peptide Fragments / blood
  • Pilot Projects
  • Prevalence
  • Remission Induction
  • Risk Assessment
  • Risk Factors
  • Tomography, X-Ray Computed
  • Ultrasonography


  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain
  • C-Reactive Protein