Gymnastics of molecular chaperones
- PMID: 20705236
- DOI: 10.1016/j.molcel.2010.07.012
Gymnastics of molecular chaperones
Abstract
Molecular chaperones assist folding processes and conformational changes in many proteins. In order to do so, they progress through complex conformational cycles themselves. In this review, I discuss the diverse conformational dynamics of the ATP-dependent chaperones of the Hsp60, Hsp70, Hsp90, and Hsp100 families.
Copyright 2010 Elsevier Inc. All rights reserved.
Similar articles
-
A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40.Int J Biochem Cell Biol. 2004 Aug;36(8):1585-98. doi: 10.1016/j.biocel.2004.01.016. Int J Biochem Cell Biol. 2004. PMID: 15147737
-
Convergent evolution of clamp-like binding sites in diverse chaperones.Nat Struct Mol Biol. 2006 Oct;13(10):865-70. doi: 10.1038/nsmb1153. Nat Struct Mol Biol. 2006. PMID: 17021621 Review.
-
Hsp70 and Hsp90--a relay team for protein folding.Rev Physiol Biochem Pharmacol. 2004;151:1-44. doi: 10.1007/s10254-003-0021-1. Epub 2004 Jan 23. Rev Physiol Biochem Pharmacol. 2004. PMID: 14740253 Review.
-
ATP-induced protein-Hsp70 complex dissociation requires K+ but not ATP hydrolysis.Nature. 1993 Oct 14;365(6447):664-6. doi: 10.1038/365664a0. Nature. 1993. PMID: 8413631
-
Molecular chaperones and protein quality control.Cell. 2006 May 5;125(3):443-51. doi: 10.1016/j.cell.2006.04.014. Cell. 2006. PMID: 16678092 Review.
Cited by
-
An RNA aptamer specific to Hsp70-ATP conformation inhibits its ATPase activity independent of Hsp40.Nucleic Acid Ther. 2015 Apr;25(2):103-12. doi: 10.1089/nat.2014.0510. Epub 2015 Feb 5. Nucleic Acid Ther. 2015. PMID: 25654640 Free PMC article.
-
Molecular chaperones: Guardians of tumor suppressor stability and function.Oncotarget. 2024 Oct 1;15:679-696. doi: 10.18632/oncotarget.28653. Oncotarget. 2024. PMID: 39352796 Free PMC article. Review.
-
The Plasmodium falciparum Hsp70-x chaperone assists the heat stress response of the malaria parasite.FASEB J. 2019 Dec;33(12):14611-14624. doi: 10.1096/fj.201901741R. Epub 2019 Nov 14. FASEB J. 2019. PMID: 31690116 Free PMC article.
-
Chaperone machines for protein folding, unfolding and disaggregation.Nat Rev Mol Cell Biol. 2013 Oct;14(10):630-42. doi: 10.1038/nrm3658. Epub 2013 Sep 12. Nat Rev Mol Cell Biol. 2013. PMID: 24026055 Free PMC article. Review.
-
Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity.Oncotarget. 2011 May;2(5):407-17. doi: 10.18632/oncotarget.272. Oncotarget. 2011. PMID: 21576760 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
