Dendritic discrimination of temporal input sequences in cortical neurons

Science. 2010 Sep 24;329(5999):1671-5. doi: 10.1126/science.1189664. Epub 2010 Aug 12.

Abstract

The detection and discrimination of temporal sequences is fundamental to brain function and underlies perception, cognition, and motor output. By applying patterned, two-photon glutamate uncaging, we found that single dendrites of cortical pyramidal neurons exhibit sensitivity to the sequence of synaptic activation. This sensitivity is encoded by both local dendritic calcium signals and somatic depolarization, leading to sequence-selective spike output. The mechanism involves dendritic impedance gradients and nonlinear synaptic N-methyl-D-aspartate receptor activation and is generalizable to dendrites in different neuronal types. This enables discrimination of patterns delivered to a single dendrite, as well as patterns distributed randomly across the dendritic tree. Pyramidal cell dendrites can thus act as processing compartments for the detection of synaptic sequences, thereby implementing a fundamental cortical computation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials
  • Animals
  • Calcium / metabolism
  • Calcium Signaling
  • Dendrites / physiology*
  • Dendrites / ultrastructure
  • Dendritic Spines / physiology*
  • Dendritic Spines / ultrastructure
  • Excitatory Postsynaptic Potentials
  • Models, Neurological
  • Pyramidal Cells / physiology*
  • Pyramidal Cells / ultrastructure
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Somatosensory Cortex / cytology
  • Somatosensory Cortex / physiology*
  • Synapses / physiology*
  • Time Factors
  • Visual Cortex / cytology
  • Visual Cortex / physiology*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Calcium