F-18 FDG PET/CT findings in pulmonary necrotizing sarcoid granulomatosis

Clin Nucl Med. 2010 Sep;35(9):697-700. doi: 10.1097/RLU.0b013e3181e9fade.

Abstract

Necrotizing sarcoid granulomatosis (NSG) is a rare systemic disease that was described by Liebow in 1973. Dyspnea and chest pain may be present, as in our first patient; however, 25% of patients are asymptomatic, as our second patient. The typical radiographic findings are nonspecific: single or multiple lung opacities, with common involvement of the pleura. To the best of our knowledge, fluorodeoxyglucose (FDG) PET has only been reported in one case of NSG, which was atypical as it occurred in an adolescent. We report 2 cases, confirming that the lesions of NSG are FDG positive, showing a typical pattern of multiple bilateral lung nodules (imaged with PET/CT in 1 case). FDG imaging has a potential role when this distribution is observed on CT, to guide the surgical biopsy and show the actual extent of the disease.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Fluorodeoxyglucose F18*
  • Granuloma / complications
  • Granuloma / diagnostic imaging*
  • Granuloma / pathology
  • Humans
  • Middle Aged
  • Necrosis
  • Positron-Emission Tomography*
  • Sarcoidosis, Pulmonary / complications
  • Sarcoidosis, Pulmonary / diagnostic imaging*
  • Sarcoidosis, Pulmonary / pathology
  • Tomography, X-Ray Computed*
  • Whole Body Imaging

Substances

  • Fluorodeoxyglucose F18