Scintigraphic findings of growth arrest lines after bisphosphonate administration in a steroid-induced osteoporosis patient: a case study

Clin Nucl Med. 2010 Sep;35(9):740-2. doi: 10.1097/RLU.0b013e3181ea3448.


Bisphosphonates inhibit bone resorption, and are used to treat patients who have low bone mineral density. This treatment results in the development of growth arrest lines, which typically appear parallel sclerotic lines to the growth plate on radiographs. We describe the case of a 14-year-old boy with steroid-induced osteoporosis, who was treated by pamidronate. This patient exhibited linearly increased bilateral uptake in the shafts of his femora, tibiae, radii, and ulnae that were parallel to the growth plates. A simple radiograph corresponding bone scan demonstrated linear sclerotic lines at the same sites.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Bone Density Conservation Agents / administration & dosage
  • Bone Density Conservation Agents / therapeutic use*
  • Diphosphonates / administration & dosage*
  • Diphosphonates / therapeutic use*
  • Growth Plate / diagnostic imaging*
  • Humans
  • Male
  • Osteoporosis / chemically induced*
  • Osteoporosis / drug therapy*
  • Radiography
  • Radionuclide Imaging
  • Steroids / adverse effects*
  • Whole Body Imaging


  • Bone Density Conservation Agents
  • Diphosphonates
  • Steroids