New insights into the development of lymphoid tissues

Nat Rev Immunol. 2010 Sep;10(9):664-74. doi: 10.1038/nri2832. Epub 2010 Aug 13.


Secondary lymphoid organs are important locations for the initiation of adaptive immune responses. They develop before birth, and their formation requires interaction between lymphotoxin-α₁ß₂-expressing lymphoid-tissue inducer cells and lymphotoxin-ß receptor-expressing stromal organizer cells. Here, we discuss new insights into the earliest phases of peripheral lymph node and Peyer's patch formation that occur before lymphotoxin-ß receptor signalling and suggest a role for the developing nervous system. In addition, we discuss the differing requirements for the postnatal formation of mucosa-associated lymphoid tissues and tertiary lymphoid structures that develop at sites of chronic inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphoid Tissue / embryology*
  • Lymphoid Tissue / growth & development*
  • Lymphoid Tissue / immunology*
  • Organogenesis / immunology*