Review
doi: 10.1038/nri2824.
Epub 2010 Aug 13.
RNA-based antiviral immunity
Affiliations
- PMID: 20706278
- DOI: 10.1038/nri2824
Item in Clipboard
Review
RNA-based antiviral immunity
Nat Rev Immunol.
2010 Sep.
Abstract
In eukaryotic RNA-based antiviral immunity, viral double-stranded RNA is recognized as a pathogen-associated molecular pattern and processed into small interfering RNAs (siRNAs) by the host ribonuclease Dicer. After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. Here, I review recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates and discuss the innate and adaptive properties of RNA-based antiviral immunity.
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