Mechanisms of Contractile-Ring Assembly in Fission Yeast and Beyond

Semin Cell Dev Biol. 2010 Dec;21(9):892-8. doi: 10.1016/j.semcdb.2010.08.004. Epub 2010 Aug 11.

Abstract

Most eukaryotes including fungi, amoebas, and animal cells assemble an actin/myosin-based contractile ring during cytokinesis. The majority of proteins implied in ring formation, maturation, and constriction are evolutionarily conserved, suggesting that common mechanisms exist among these divergent eukaryotes. Here, we review the recent advances in positioning and assembly of the actomyosin ring in the fission yeast Schizosaccharomyces pombe, the budding yeast Saccharomyces cerevisiae, and animal cells. In particular, major findings have been made recently in understanding ring formation in genetically tractable S. pombe, revealing a dynamic and robust search, capture, pull, and release mechanism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Division
  • Cytokinesis*
  • Humans
  • Schizosaccharomyces / cytology*
  • Schizosaccharomyces / metabolism