Fulminant Cryptosporidiosis Associated With Digestive Adenocarcinoma in SCID Mice Infected With Cryptosporidium Parvum TUM1 Strain

Int J Parasitol. 2010 Nov;40(13):1469-75. doi: 10.1016/j.ijpara.2010.07.007. Epub 2010 Aug 12.

Abstract

We recently demonstrated that Cryptosporidium parvum IOWA strain induces in situ ileo-caecal adenocarcinoma in an animal model. Herein, the ability of another C. parvum strain to induce digestive neoplasia in dexamethasone-treated SCID mice was explored. SCID mice infected with C. parvum TUM1 strain developed a fulminant cryptosporidiosis associated with intramucosal adenocarcinoma, which is considered an early histological sign of invasive cancer. Both evidence of a role of C. parvum in adenocarcinoma induction and the extended prevalence of cryptosporidiosis worldwide, suggest that the risk of C. parvum-induced gastro-intestinal cancer in humans should be assessed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / complications*
  • Adenocarcinoma / pathology
  • Animals
  • Carcinoma in Situ / pathology
  • Cryptosporidiosis / complications*
  • Cryptosporidium parvum / pathogenicity*
  • Histocytochemistry
  • Intestinal Mucosa / pathology
  • Intestinal Neoplasms / complications*
  • Intestinal Neoplasms / pathology
  • Iowa
  • Mice
  • Mice, SCID