Hypoxia inducible factor 1 (HIF-1) and cardioprotection

Acta Pharmacol Sin. 2010 Sep;31(9):1085-94. doi: 10.1038/aps.2010.132. Epub 2010 Aug 16.


Since its discovery in early 1990s, hypoxia inducible factor 1 (HIF-1) has been increasingly recognized for its key role in transcriptional control of more than a hundred genes that regulate a wide-spectrum of cellular functional events, including angiogenesis, vasomotor control, glucose and energy metabolism, erythropoiesis, iron homeostasis, pH regulation, cell proliferation and viability. Evidence accumulated during the past 7 years suggests a critical role for HIF-1alpha in mediating cardioprotection. The purpose of our present article is to provide an updated overview on this important regulator of gene expression in the cellular stress-responsive and adaptive process. We have particularly emphasized the involvement of HIF-1 in the induction of cardioprotective molecules, such as inducible nitric oxide synthase (iNOS), hemeoxygenase 1 (HO-1), and erythropoietin (EPO), which in turn alleviate myocardial damages caused by harmful events such as ischemia-reperfusion injury. Despite these advances, further in-depth studies are needed to elucidate the possible coordination or interaction between HIF-1alpha and other key transcription factors in regulating protein expression that leads to cardioprotection.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiotonic Agents / metabolism*
  • Gene Expression Regulation*
  • Humans
  • Hypoxia-Inducible Factor 1 / genetics
  • Hypoxia-Inducible Factor 1 / metabolism*
  • Myocardial Infarction / metabolism
  • Myocardium / metabolism*
  • Myocardium / pathology
  • Reperfusion Injury / metabolism


  • Cardiotonic Agents
  • Hypoxia-Inducible Factor 1