Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins

Periodontol 2000. 2010 Oct;54(1):15-44. doi: 10.1111/j.1600-0757.2010.00377.x.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adhesins, Bacterial / metabolism*
  • Animals
  • Antimicrobial Cationic Peptides / metabolism
  • Bacterial Adhesion / physiology
  • Chronic Periodontitis / immunology
  • Chronic Periodontitis / microbiology
  • Complement Activation
  • Cysteine Endopeptidases / metabolism*
  • Gingipain Cysteine Endopeptidases
  • Gingiva / microbiology
  • Heme / metabolism
  • Humans
  • Immune Evasion / physiology
  • Immunity, Innate / physiology
  • Inflammation / microbiology
  • Porphyromonas gingivalis / enzymology*
  • Protein Denaturation
  • Receptors, Proteinase-Activated / metabolism
  • Signal Transduction
  • Substrate Specificity
  • Virulence Factors*

Substances

  • Adhesins, Bacterial
  • Antimicrobial Cationic Peptides
  • Gingipain Cysteine Endopeptidases
  • Receptors, Proteinase-Activated
  • Virulence Factors
  • Heme
  • Cysteine Endopeptidases