Highly efficient procedure for the synthesis of fructone fragrance using a novel carbon based acid

Molecules. 2010 Aug 5;15(8):5369-77. doi: 10.3390/molecules15085369.


The novel carbon based acid has been synthesized via one-step hydrothermal carbonization of furaldehyde and hydroxyethylsulfonic acid. A highly efficient procedure for the synthesis of fructone has been developed using the novel carbon based acid. The results showed that the catalyst possessed high activity for the reaction, giving a yield of over 95%. The advantages of high activity, stability, reusability and low cost for a simple synthesis procedure and wide applicability to various diols and beta-keto esters make this novel carbon based acid one of the best choices for the reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetoacetates / chemistry*
  • Alcohols / chemistry
  • Carbon / chemistry*
  • Catalysis
  • Chemistry, Organic / methods*
  • Esters / chemistry
  • Heterocyclic Compounds, 1-Ring / chemical synthesis*
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Isethionic Acid / chemistry*
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Microscopy, Electron, Scanning
  • Perfume / chemical synthesis*
  • Perfume / chemistry
  • Solvents / chemistry
  • Spectrophotometry, Infrared
  • Time Factors


  • Acetoacetates
  • Alcohols
  • Esters
  • Heterocyclic Compounds, 1-Ring
  • Ketones
  • Perfume
  • Solvents
  • Carbon
  • Isethionic Acid