Cyclothiazomycin, a novel polythiazole-containing peptide with renin inhibitory activity. Taxonomy, fermentation, isolation and physico-chemical characterization

J Antibiot (Tokyo). 1991 Jun;44(6):582-8. doi: 10.7164/antibiotics.44.582.

Abstract

Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp. NR0516. It was isolated from fermentation broth by extraction with butyl alcohol, QAE-Toyopearl column chromatography and preparative HPLC. Cyclothiazomycin, which was determined to be a unique polythiazole-containing bicyclic peptide, exhibited inhibitory activity against human plasma renin with IC50 being 1.7 microM.

MeSH terms

  • Angiotensin I / analysis
  • Animals
  • Chromatography, High Pressure Liquid
  • Fermentation
  • Humans
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Peptides, Cyclic / biosynthesis
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification
  • Peptides, Cyclic / pharmacology*
  • Radioimmunoassay
  • Renin / antagonists & inhibitors*
  • Soil Microbiology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Streptomyces / classification
  • Streptomyces / metabolism*
  • Thiazoles / chemistry
  • Thiazoles / isolation & purification
  • Thiazoles / pharmacology*

Substances

  • Peptides, Cyclic
  • Thiazoles
  • cyclothiazomycin
  • Angiotensin I
  • Renin