A novel synthetic route for the anti-HIV drug MC-1220 and its analogues

ChemMedChem. 2010 Nov 8;5(11):1847-9. doi: 10.1002/cmdc.201000244.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / pharmacology*
  • Fluorobenzenes
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • HIV Reverse Transcriptase / metabolism
  • HIV-1 / classification
  • HIV-1 / drug effects*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Pyrimidinones / chemical synthesis*
  • Pyrimidinones / chemistry
  • Pyrimidinones / pharmacology*
  • Structure-Activity Relationship

Substances

  • 6-(1-(2,6-difluorophenyl)ethyl)-2-(dimethylamino)-5-methylpyrimidin-4(3H)-one
  • Anti-HIV Agents
  • Fluorobenzenes
  • Pyrimidinones
  • HIV Reverse Transcriptase