Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep;11(9):642-51.
doi: 10.1038/nrn2884. Epub 2010 Aug 18.

The Neurobiology of Psychedelic Drugs: Implications for the Treatment of Mood Disorders

Affiliations
Review

The Neurobiology of Psychedelic Drugs: Implications for the Treatment of Mood Disorders

Franz X Vollenweider et al. Nat Rev Neurosci. .

Abstract

After a pause of nearly 40 years in research into the effects of psychedelic drugs, recent advances in our understanding of the neurobiology of psychedelics, such as lysergic acid diethylamide (LSD), psilocybin and ketamine have led to renewed interest in the clinical potential of psychedelics in the treatment of various psychiatric disorders. Recent behavioural and neuroimaging data show that psychedelics modulate neural circuits that have been implicated in mood and affective disorders, and can reduce the clinical symptoms of these disorders. These findings raise the possibility that research into psychedelics might identify novel therapeutic mechanisms and approaches that are based on glutamate-driven neuroplasticity.

Similar articles

See all similar articles

Cited by 105 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback