[The effect of aspirin and indomethacin on intracellular pH and on the activation of the Na+/H+ antiporter in neutrophils]

Izv Akad Nauk SSSR Biol. 1991 Mar-Apr:(2):169-75.
[Article in Russian]

Abstract

Using microfluorometry, aspirin and indomethacine effects on intracellular pH and Na+/H+ neutrophilic antiporter activation were studied. Aspirin and indomethacine were shown to decrease intracellular pH of quiescent neutrophil cells. Aspirin completely blocked basifying of cytoplasm, which is resulted from Na+/H+ neutrophilic antiporter activation.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Aspirin / pharmacology*
  • Biological Transport / drug effects
  • Bradykinin / pharmacology
  • Cells, Cultured / drug effects
  • Cells, Cultured / metabolism
  • Concanavalin A / pharmacology
  • Cytoplasm / drug effects
  • Cytoplasm / metabolism
  • Humans
  • Hydrogen / blood*
  • Hydrogen-Ion Concentration
  • Indomethacin / pharmacology*
  • Neutrophils / drug effects*
  • Neutrophils / metabolism
  • Sodium / blood*

Substances

  • Concanavalin A
  • Hydrogen
  • Sodium
  • Aspirin
  • Bradykinin
  • Indomethacin