Anti-allergic activity of a platycodon root ethanol extract

Int J Mol Sci. 2010 Jul 16;11(7):2746-58. doi: 10.3390/ijms11072746.


Platycodon grandiflorum (Campanulaceae) is used as traditional medicine in Asian countries. In Korean traditional medicine, Platycodon root has been widely used since ancient times as a traditional drug to treat cold, cough and asthma. However, its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms remain unknown. In this study, the biological effect of Platycodon root ethanol extract (PE) was evaluated in BMMC after induction of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187) stimulation. The effect of PE on the production of several allergic mediators, such as interleukin-6 (IL-6), prostaglandin D(2) (PGD(2)), leukotriene C(4) (LTC(4)), beta-Hexosaminidase (beta-Hex) and cyclooxygenase-2 (COX-2) protein, was investigated. The results demonstrate that PE inhibits PMA + A23187 induced production of IL-6, PGD(2), LTC(4), beta-Hexosaminidase and COX-2 protein. Taken together, these results indicate that PE has the potential for use in the treatment of allergy.

Keywords: Platycodon root; antiallergy; bone marrow-derived mast cell; cyclooxygenase-2; leukotriene C4; prostaglandin D2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Allergic Agents / chemistry
  • Anti-Allergic Agents / pharmacology*
  • Bone Marrow Cells / drug effects
  • Bone Marrow Cells / immunology
  • Bone Marrow Cells / metabolism
  • Cell Degranulation / drug effects
  • Cell Survival / drug effects
  • Cyclooxygenase 2 / metabolism
  • Interleukin-6 / metabolism
  • Leukotriene C4 / biosynthesis
  • Male
  • Mast Cells / drug effects
  • Mast Cells / immunology
  • Mast Cells / metabolism
  • Mice
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Roots / chemistry*
  • Platycodon / chemistry*
  • Prostaglandin D2 / biosynthesis


  • Anti-Allergic Agents
  • Interleukin-6
  • Plant Extracts
  • Leukotriene C4
  • Cyclooxygenase 2
  • Prostaglandin D2