Scaling up human papillomavirus vaccination: a conceptual framework of vaccine adherence

Sex Health. 2010 Sep;7(3):279-86. doi: 10.1071/SH09130.


This review article provides a conceptual framework for human papillomavirus (HPV) vaccine acceptance and adherence, with a focus on improving understanding of the sociocultural factors impacting vaccine adherence behaviour. We include a systematic review of the slowly expanding literature on HPV vaccine acceptability and uptake in developed nations, as well as the relatively few publications from poorer nations, where more than 80% of global cervical cancer related deaths occur and where the vaccine will probably have the largest impact. We suggest that this conceptual framework will not only improve our understanding of HPV vaccine uptake and adherence, but it may also guide future sociobehavioural research geared towards improving adherence to the HPV vaccine and other multi-step vaccines in a young population at risk for sexually transmissible infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Adolescent
  • Child
  • Developed Countries*
  • Developing Countries*
  • Female
  • Health Education / organization & administration
  • Health Knowledge, Attitudes, Practice
  • Health Plan Implementation / organization & administration
  • Humans
  • Mass Vaccination / organization & administration*
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / administration & dosage*
  • Patient Acceptance of Health Care
  • Sexually Transmitted Diseases, Viral / prevention & control*
  • Uterine Cervical Neoplasms / prevention & control*


  • Papillomavirus Vaccines