Regulatory RNAs Derived From Transfer RNA?

RNA. 2010 Oct;16(10):1865-9. doi: 10.1261/rna.2266510. Epub 2010 Aug 18.

Abstract

Four recent studies suggest that cleavages of transfer RNAs generate products with microRNA-like features, with some evidence of function. If their regulatory functions were to be confirmed, these newly revealed RNAs would add to the expanding repertoire of small noncoding RNAs and would also provide new perspectives on the coevolution of transfer RNA and messenger RNA.

Publication types

  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Humans
  • MicroRNAs / genetics*
  • MicroRNAs / metabolism*
  • Models, Biological
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA, Transfer / genetics*
  • RNA, Transfer / metabolism*
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism
  • Regulatory Sequences, Ribonucleic Acid / genetics*

Substances

  • MicroRNAs
  • RNA, Messenger
  • RNA, Untranslated
  • Regulatory Sequences, Ribonucleic Acid
  • RNA, Transfer