Abstract
An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antiviral Restriction Factors
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Capsid Proteins / metabolism
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Carrier Proteins / metabolism*
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Cyclophilin A / metabolism*
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HIV Infections / immunology*
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HIV Infections / virology
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HIV Integrase / metabolism*
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HIV-1 / pathogenicity
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HIV-1 / physiology*
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Host-Pathogen Interactions
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Humans
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Tripartite Motif Proteins
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Ubiquitin-Protein Ligases
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Viral Core Proteins / metabolism
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Virus Integration*
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Virus Replication
Substances
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Antiviral Restriction Factors
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Capsid Proteins
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Carrier Proteins
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Tripartite Motif Proteins
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Viral Core Proteins
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TRIM5 protein, human
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Ubiquitin-Protein Ligases
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HIV Integrase
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Cyclophilin A