A new functional role of HIV-1 integrase during uncoating of the viral core

Immunol Res. 2010 Dec;48(1-3):14-26. doi: 10.1007/s12026-010-8164-z.

Abstract

An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antiviral Restriction Factors
  • Capsid Proteins / metabolism
  • Carrier Proteins / metabolism*
  • Cyclophilin A / metabolism*
  • HIV Infections / immunology*
  • HIV Infections / virology
  • HIV Integrase / metabolism*
  • HIV-1 / pathogenicity
  • HIV-1 / physiology*
  • Host-Pathogen Interactions
  • Humans
  • Tripartite Motif Proteins
  • Ubiquitin-Protein Ligases
  • Viral Core Proteins / metabolism
  • Virus Integration*
  • Virus Replication

Substances

  • Antiviral Restriction Factors
  • Capsid Proteins
  • Carrier Proteins
  • Tripartite Motif Proteins
  • Viral Core Proteins
  • TRIM5 protein, human
  • Ubiquitin-Protein Ligases
  • HIV Integrase
  • Cyclophilin A