Abstract
PdCl(2)(MeCN)(2) in combination with dppp proved to be a powerful and efficient catalyst for the coupling of sterically hindered N-arylsulfonylhydrazones with aryl halides, thus providing a flexible and convergent access to tetrasubstituted olefins related to iso-combretastatin A4 in good yields. This new protocol has been applied successfully to the formal synthesis of biphenylisopropylidene 4-pyridine CYP17 inhibitor, 12b, of biological interest.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkenes / chemical synthesis*
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Alkenes / pharmacology
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Catalysis
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Halogens / chemistry*
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Hydrazones / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Stereoisomerism
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Steroid 17-alpha-Hydroxylase / antagonists & inhibitors
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Stilbenes / chemistry*
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Stilbenes / pharmacology
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Tubulin / chemistry
Substances
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Alkenes
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Halogens
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Hydrazones
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Stilbenes
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Tubulin
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Palladium
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Steroid 17-alpha-Hydroxylase
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fosbretabulin