Fitness variation due to sexual antagonism and linkage disequilibrium

Evolution. 2010 Dec;64(12):3638-42. doi: 10.1111/j.1558-5646.2010.01100.x.


Extensive fitness variation for sexually antagonistic characters has been detected in nature. However, current population genetic theory suggests that sexual antagonism is unlikely to play a major role in the maintenance of variation. We present a two-locus model of sexual antagonism that is capable of explaining greater fitness variance at equilibrium than previous single-locus models. The second genetic locus provides additional fitness variance in two complementary ways. First, linked loci can maintain gene variants that are lost in single-locus models of evolution, expanding the opportunity for polymorphism. Second, linkage disequilibrium results between any two sexually antagonistic genes, producing an excess of high- and low-fitness haplotypes. Our results uncover a unique contribution of conflicting selection pressures to the maintenance of variation, which simpler models that neglect genetic architecture overlook.

MeSH terms

  • Animals
  • Female
  • Genetic Fitness*
  • Genetic Variation*
  • Haplotypes
  • Linkage Disequilibrium
  • Male
  • Models, Biological
  • Polymorphism, Genetic
  • Sex Characteristics