NFAT, immunity and cancer: a transcription factor comes of age

Nat Rev Immunol. 2010 Sep;10(9):645-56. doi: 10.1038/nri2818. Epub 2010 Aug 20.


Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It is now clear that NFAT proteins have important functions in other cells of the immune system and regulate numerous developmental programmes in vertebrates. Dysregulation of these programmes can lead to malignant growth and cancer. This Review focuses on recent advances in our understanding of the transcriptional functions of NFAT proteins in the immune system and provides new insights into their potential roles in cancer development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • NFATC Transcription Factors / immunology*
  • Neoplasms / immunology*
  • Neoplasms / metabolism*
  • Signal Transduction / immunology*
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism
  • Transcription Factors / immunology
  • Transcription, Genetic


  • NFATC Transcription Factors
  • Transcription Factors