Topiramate responsive exploding head syndrome

J Clin Sleep Med. 2010 Aug 15;6(4):382-3.


Exploding head syndrome is a rare phenomenon but can be a significant disruption to quality of life. We describe a 39-year-old female with symptoms of a loud bang and buzz at sleep onset for 3 years. EEG monitoring confirmed these events occurred in transition from stage 1 sleep. This patient reported improvement in intensity of events with topiramate medication. Based on these results, topiramate may be an alternative method to reduce the intensity of events in exploding head syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anticonvulsants / therapeutic use*
  • Auditory Perceptual Disorders / diagnosis
  • Auditory Perceptual Disorders / drug therapy*
  • Dose-Response Relationship, Drug
  • Female
  • Fructose / analogs & derivatives*
  • Fructose / therapeutic use
  • Humans
  • Illusions*
  • Migraine with Aura / diagnosis
  • Migraine with Aura / drug therapy*
  • Polysomnography
  • Sleep-Wake Transition Disorders / diagnosis
  • Sleep-Wake Transition Disorders / drug therapy*
  • Topiramate


  • Anticonvulsants
  • Topiramate
  • Fructose