Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability

Drug Discov Today. 2010 Nov;15(21-22):958-65. doi: 10.1016/j.drudis.2010.08.007. Epub 2010 Aug 17.

Abstract

Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them to be administered as a unit dosage form for per-oral administration. When such a system is released in the lumen of the gastrointestinal tract, it disperses to form a fine emulsion (micro/nano) with the aid of GI fluid. This leads to in situ solubilization of drug that can subsequently be absorbed by lymphatic pathways, bypassing the hepatic first-pass effect. This article presents an exhaustive account of various literature reports on diverse types of self-emulsifying formulations with emphasis on their formulation, characterization and in vitro analysis, with examples of currently marketed preparations.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Biological Availability
  • Chemistry, Pharmaceutical
  • Drug Delivery Systems*
  • Emulsifying Agents
  • Emulsions* / analysis
  • Emulsions* / chemistry
  • Excipients
  • Humans
  • Lipids*
  • Pharmaceutical Preparations / administration & dosage*
  • Solubility
  • Surface-Active Agents / chemistry*

Substances

  • Emulsifying Agents
  • Emulsions
  • Excipients
  • Lipids
  • Pharmaceutical Preparations
  • Surface-Active Agents