Medication-related problems in CKD

Adv Chronic Kidney Dis. 2010 Sep;17(5):404-12. doi: 10.1053/j.ackd.2010.06.004.


Patients with CKD are often prescribed heterogeneous medications to treat disease-associated comorbidities, to slow down progression of the disease, and to minimize morbidity and mortality rates. However, the medication regimens of this population are very complex, leading to an increased potential for medication-related problems (MRPs). As kidney function declines, the type and amount of medications a patient consumes increases, thereby putting them at a higher risk for MRPs. MRPs have been known to be associated with morbidity, mortality, and a lower quality of life. This review will summarize data on the prevalence and effect of MRPs, and strategies that can be used by clinicians to reduce and resolve MRPs.

Publication types

  • Review

MeSH terms

  • Community Participation
  • Comorbidity
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Drug Therapy* / economics
  • Drug Therapy* / mortality
  • Drug Therapy* / statistics & numerical data
  • Drug-Related Side Effects and Adverse Reactions
  • Hospitalization / economics
  • Humans
  • Kidney Failure, Chronic* / epidemiology
  • Kidney Failure, Chronic* / physiopathology
  • Kidney Failure, Chronic* / therapy
  • Quality of Life
  • Treatment Failure