Discordant expression of miR-103/7 and pantothenate kinase host genes in mouse

Mol Genet Metab. 2010 Oct-Nov;101(2-3):292-5. doi: 10.1016/j.ymgme.2010.07.016. Epub 2010 Aug 4.

Abstract

miR-103 and miR-107, microRNAs hosted by pantothenate kinase genes, are proposed to regulate cellular lipid metabolism. microRNA-mediated regulation is complex, potentially affecting expression of the host gene, related enzymes within the same pathway, or apparently distinct targets. Using qRT-PCR, we demonstrate that miR-103 and miR-107 expression does not correlate with expression of host pantothenate kinase genes in mouse tissues. The miR-103/7 family thus provides an intriguing model for dissecting microRNA transcription, processing and coordinated function within host genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Male
  • Mice
  • MicroRNAs / biosynthesis
  • MicroRNAs / genetics*
  • Phosphotransferases (Alcohol Group Acceptor) / biosynthesis*
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • MIRN103 microRNA, mouse
  • MIRN107 microRNA, mouse
  • MicroRNAs
  • Phosphotransferases (Alcohol Group Acceptor)
  • pantothenate kinase