p53, ROS and senescence in the control of aging

Aging (Albany NY). 2010 Aug;2(8):471-4. doi: 10.18632/aging.100189.


In addition to its function as a tumour suppressor, p53 is also involved in an increasing number of pathology associated with aging. Several activities of p53 appear contribute to its role in aging; one function that might be particularly relevant in this context is the regulation of senescence. The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.

Publication types

  • Review

MeSH terms

  • Aging* / physiology
  • Animals
  • Apoptosis / physiology
  • Cells, Cultured
  • Cellular Senescence / physiology
  • DNA Damage
  • Genes, p53*
  • Humans
  • Longevity / genetics*
  • Mice
  • Oxidative Stress / physiology
  • Reactive Oxygen Species / toxicity*
  • TOR Serine-Threonine Kinases / physiology
  • Tumor Suppressor Protein p53 / physiology*


  • Reactive Oxygen Species
  • Tumor Suppressor Protein p53
  • TOR Serine-Threonine Kinases