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. 2009 Mar;2(3):44-50.

Clinical Efficacy of Self-applied Blue Light Therapy for Mild-to-Moderate Facial Acne

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Clinical Efficacy of Self-applied Blue Light Therapy for Mild-to-Moderate Facial Acne

Michael H Gold et al. J Clin Aesthet Dermatol. .
Free PMC article

Abstract

This study was an evaluation of the performance of self-applied, blue light, light-emitting diode therapy in the treatment of mild-to-moderate inflammatory acne on the face, concerning: 1) time to improvement and/or resolution of the number of blemishes and lesions on the face; 2) quality of skin condition; 3) occurrence and count of the number of new blemishes and lesions; and 4) ease of product use; patient comfort, wellbeing, and satisfaction during the treatment period; and safety of treatment. Subjects (N=21) were included according to the inclusion/exclusion criteria and after they had given informed consent. The blue light treatment was conducted over an eight-week period. For study data management and analysis, SPSS 16.0 statistical software was used. Data management and analysis was performed independently using, where appropriate, ANOVA, student t-test, and Mann-Whitney test for N=20. Tests were carried out at the five-percent significance level. The confidence interval was 95 percent. Twenty-one subjects concluded the study (18/21 were female and 3/21 were male). Upon the first outbreak of acne, subjects had a mean age of 15 years (range 8-28 years), and 19 subjects had mild-to-moderate acne for a mean duration of 13.1 years. During the study period with self-applied blue light treatment, the total number of comedones on the face had significantly reduced for the assessment at Day 7 (p<0.019) and at Day 28 (p<0.001). The total number of open comedones (blackheads) on the face during the treatment period was reduced significantly (p<0.02) for assessment at treatment Day 7 (p<0.005) and for the assessment at Day 28. The total number of closed comedones (whiteheads) on the face during the treatment period, was reduced significantly (p<0.007) for the assessment at Day 28. The total number of papules during treatment had reduced significantly for assessment at Day 7 (p<0.048) and Day 28 (p<0.005). The total number of pustules during treatment had reduced, but this difference was not statistically significant. This was similar for nodules present. Subjects expressed confidence in using the self-applied blue light without the supervision of a doctor. Regarding previous treatments, subjects expressed dissatisfaction and considered self-applied blue light treatment to be better for their condition. Self-applied blue light treatment was reported to be easy and safe to use.

Figures

Figure 1
Figure 1
Evolution of lesions during the TC treatment period.

The number of lesions given is the mean number of lesions measured within the individual subjects during the eight-week treatment period

Time is given as measure points during the visits: TX0 to TX5. During the phone call (24 hours after the start of the study), there was no measurement performed on the items presented in the graph

Figure 2
Figure 2
Physical experience reported during TC treatment.

The value is given as a mean on a five-point scale, (1 = strongly disagree; 5 = strongly agree) for all the items given in the graph except the amount of pain

Time is given as the measurement points at the visits

Treatment was painful—pain was measured during treatment using a five-point scale (1 = strongly disagree, 5 = strongly agree)

Amount of pain = when pain was experienced, the level of pain was measured on a VAS 10cm scale, where a stroke was placed on a 10cm line.

Figure 3
Figure 3
Experience upon conducting treatment with TC.

The value is given as a mean on a five-point scale, (1 = strongly disagree, 5 = strongly agree) for all the items given in the graph, except the amount of pain. See Figure 2 notes for how amount of pain was measured.

Time is given as the measurement points at the visits

Figures 4a and b
Figures 4a and b
This female patient had her first outbreak of acne at the age of 17. Baseline (a) and after the eight-week treatment period (b). The total number of lesions had reduced by 62 percent.
Figures 5a and b
Figures 5a and b
This 28-year old male patient had the first outbreak of acne at the age of 23. Baseline (a) and after the eight-week treatment period (b). The total number of lesions had reduced by 94 percent. The number of open comedones was reduced by 100 percent, the number of closed comedones was reduced by 100 percent, and the number of papules was reduced by 84 percent. There were no pustules or nodules present at the start and end of treatment.

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