Kinesin-14: the roots of reversal

BMC Biol. 2010 Aug 16;8:107. doi: 10.1186/1741-7007-8-107.

Abstract

Kinesin-14 motor proteins step towards microtubule minus ends, in the opposite direction to other kinesins. Work on the still-enigmatic kinesin-14 mechanism published in BMC Structural Biology shows that the carboxyl terminus of the motor head undergoes a dock-undock cycle, like that of plus-end-directed kinesins.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Drosophila / chemistry
  • Drosophila / metabolism
  • Drosophila Proteins / chemistry
  • Drosophila Proteins / metabolism
  • Humans
  • Kinesin / chemistry*
  • Kinesin / metabolism*
  • Protein Binding
  • Protein Conformation

Substances

  • Drosophila Proteins
  • Kinesin