Prevalence of G6PD deficiency in a large cohort of HIV-infected patients

J Infect. 2010 Nov;61(5):399-402. doi: 10.1016/j.jinf.2010.08.003. Epub 2010 Aug 21.

Abstract

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect. Screening for this condition in HIV-infected patients from susceptible ethnic groups is recommended based on expert opinion. Here we determined the prevalence of G6PD deficiency and the occurrence of G6PD-related hemolytic events in a large cohort of patients.

Methods: We identified all HIV-infected adults who presented as new patients at a single urban HIV clinic between 02/01/2007 and 01/31/2009. Demographic and laboratory data including G6PD results were collected. In addition, outpatient and inpatient medical records of G6PD deficient patients were reviewed for episodes of hemolytic anemia.

Results: A total of 1172 patients were identified and G6PD testing was performed in 1110 (94.7%). Overall, 75 (6.8%) subjects had G6PD deficiency. Rates were higher among African Americans (68/699; 9.7%) and Hispanics (5/253; 2.0%). Only one non-Hispanic White subject had G6PD deficiency (1/153; 0.7%). At baseline, hemoglobin concentrations were similar among subjects with or without G6PD deficiency. Among patients with G6PD deficiency, 40 (53.3%) were prescribed trimethoprim-sulfamethoxazole or dapsone. During follow-up, five (6.7%) of these patients developed acute hemolytic anemia.

Discussion: These results provide strong clinical evidence for recommending G6PD testing in HIV-infected subjects from susceptible ethnic backgrounds.

MeSH terms

  • Adult
  • African Americans / statistics & numerical data*
  • Aged
  • Anemia, Hemolytic / complications
  • Anemia, Hemolytic / epidemiology
  • Anti-Infective Agents / therapeutic use
  • Cohort Studies
  • Dapsone / therapeutic use
  • Drug Combinations
  • European Continental Ancestry Group / statistics & numerical data
  • Female
  • Glucosephosphate Dehydrogenase / blood
  • Glucosephosphate Dehydrogenase Deficiency / blood
  • Glucosephosphate Dehydrogenase Deficiency / complications
  • Glucosephosphate Dehydrogenase Deficiency / drug therapy
  • Glucosephosphate Dehydrogenase Deficiency / epidemiology*
  • HIV Infections / complications
  • HIV Infections / epidemiology
  • Hispanic Americans / statistics & numerical data*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • Sulfamethizole / therapeutic use
  • Texas / epidemiology
  • Trimethoprim / therapeutic use
  • Urban Population
  • Young Adult

Substances

  • Anti-Infective Agents
  • Drug Combinations
  • Sulfamethizole
  • trimethoprim sulfamethizole
  • Dapsone
  • Trimethoprim
  • Glucosephosphate Dehydrogenase