Association between pulse wave velocity and nerve conduction study in diabetic patients

Eur Neurol. 2010;64(4):219-23. doi: 10.1159/000319605. Epub 2010 Aug 20.


Background/aims: Brachial-ankle pulse wave velocity (baPWV) is a marker of vascular stiffness and is reported to be associated with diabetic neuropathy; however, the relationship between baPWV and nerve conduction study (NCS) has yet to be examined.

Methods: Between January 2006 and December 2008, we investigated this relationship in diabetic patients. To this end, we reviewed the medical records of 100 diabetic patients for whom both baPWV and NCS had been examined.

Results: The mean age of patients was 55.4 ± 10.6 years, and the mean duration of diabetes mellitus was 6.3 ± 7.3 years. A statistically significant inverse correlation between baPWV and NCS was observed, especially in the lower extremity sensory NCS [superficial peroneal sensory nerve action potential (SNAP), r = -0.466, p <0.05; sural SNAP, r = -0.384, p <0.01]. A multiple linear regression analysis also demonstrated a significant association between baPWV and some parameters of NCS (SNAP of sural nerve, and nerve conduction velocity of peroneal and sural nerves).

Conclusion: These results indicate that the degree of systemic arterial stiffness is associated with peripheral nerve status in diabetic patients, but it is unclear what this signifies and further study is needed.

MeSH terms

  • Adult
  • Aged
  • Ankle / physiopathology
  • Biophysics
  • Brachial Plexus / physiopathology
  • Diabetes Mellitus / pathology
  • Diabetes Mellitus / physiopathology*
  • Electric Stimulation / methods
  • Electromyography / methods
  • Evoked Potentials, Somatosensory / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neural Conduction / physiology*
  • Pulsatile Flow*
  • Reaction Time / physiology
  • Retrospective Studies
  • Statistics as Topic
  • Sural Nerve / physiopathology
  • Tibial Nerve / physiopathology