Contrasting tissue factors predict heterogeneous striatal dopamine neurotoxicity after MPTP or methamphetamine treatment

Brain Res. 1990 Nov 26;534(1-2):348-51. doi: 10.1016/0006-8993(90)90156-6.


Treatment of mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or (+)-methamphetamine (METH) results in regionally heterogeneous patterns of dopaminergic depletion. The magnitude of the MPTP-induced dopamine (DA) depletion corresponds directly to the density of [3H]mazindol binding to DA transport sites, but not the DA concentration, in intact mouse striatal regions. In contrast, the extent of METH-induced DA depletion corresponds to the intact dopamine concentration, not the [3H]mazindol binding, in the same striatal regions. The findings provide a rationale for testing different hypotheses regarding the neurobiological substrates of mesostriatal injury in idiopathic Parkinson's disease (PD).

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism
  • Corpus Striatum / pathology*
  • Dopamine / metabolism*
  • MPTP Poisoning*
  • Male
  • Mazindol / metabolism
  • Methamphetamine / toxicity*
  • Mice
  • Nervous System / drug effects
  • Neurotoxins
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / metabolism


  • Neurotoxins
  • Receptors, Dopamine
  • Methamphetamine
  • Mazindol
  • Dopamine