The first 2 cases of granulocyte colony-stimulating factor producing adenocarcinoma of the uterine cervix

Int J Gynecol Pathol. 2010 Sep;29(5):483-7. doi: 10.1097/PGP.0b013e3181d29729.


Granulocyte colony-stimulating factor (G-CSF)-producing nonhematopoietic malignancies have been reported in various organs, and most of them have been associated with poor clinical outcome. However, because of the rarity of the reported cases, information regarding the G-CSF-producing gynecological malignancies is limited. We report the first 2 cases of G-CSF-producing cervical adenocarcinomas, which exhibited an aggressive clinical course. At initial diagnosis, both patients exhibited marked leukocytosis without an obvious sign of infections. Of these, one was initially treated with definitive radiotherapy and the other was treated with radical surgery. However, both of these patients experienced recurrences in a short period and died from disease progression in less than 6 months. According to the facts that the tumor cells were positive for G-CSF, the elevated serum level of G-CSF, and their clinical course correlated well with the white blood cell count, we concluded that these tumors were G-CSF-producing cancers. These cases strongly indicate the aggressive nature of the G-CSF-producing cervical adenocarcinomas.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / pathology
  • Adenocarcinoma / therapy
  • Aged
  • Antineoplastic Agents / therapeutic use
  • Combined Modality Therapy
  • Enzyme-Linked Immunosorbent Assay
  • Fatal Outcome
  • Female
  • Granulocyte Colony-Stimulating Factor / biosynthesis*
  • Granulocyte Colony-Stimulating Factor / blood
  • Gynecologic Surgical Procedures
  • Humans
  • Immunohistochemistry
  • Leukocyte Count
  • Middle Aged
  • Radiotherapy
  • Uterine Cervical Neoplasms / metabolism*
  • Uterine Cervical Neoplasms / pathology
  • Uterine Cervical Neoplasms / therapy


  • Antineoplastic Agents
  • Granulocyte Colony-Stimulating Factor