Long-term effects of coordinative training in degenerative cerebellar disease

Mov Disord. 2010 Oct 15;25(13):2239-46. doi: 10.1002/mds.23222.


Few clinical studies have evaluated physiotherapeutic interventions for patients with degenerative cerebellar disease. In particular, evidence for long-term effects and transfer to activities of daily life is rare. We have recently shown that coordinative training leads to short-term improvements in motor performance. To evaluate long-term benefits and translation to real world function, we here assessed motor performance and achievements in activities of daily life 1 year after a 4 week intensive coordinative training, which was followed by a home training program. Effects were assessed by clinical rating scales, a goal attainment score and quantitative movement analysis. Despite gradual decline of motor performance and gradual increase of ataxia symptoms due to progression of disease after 1 year, improvements in motor performance and achievements in activities of daily life persisted. Thus, also in patients with degenerative cerebellar disease, continuous coordinative training leads to long-term improvements, which translate to real world function.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Cerebellar Diseases / complications
  • Cerebellar Diseases / rehabilitation*
  • Disability Evaluation
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Movement / physiology
  • Neurodegenerative Diseases / complications
  • Neurodegenerative Diseases / rehabilitation*
  • Physical Therapy Modalities*
  • Psychomotor Performance / physiology*
  • Treatment Outcome