Nanotoxicology of metal wear particles in total joint arthroplasty: a review of current concepts

J Appl Biomater Biomech. 2010 Jan-Apr;8(1):1-6.


Metal-on-metal (M-M) joint replacement has raised concerns about the long-term effects of metal wear debris and corrosion products. This review summarizes the current concepts in biological reactivity to metal wear particles, ions, and corrosion products. Attention is focused on Co-Cr-Mo alloy since it is the most diffused and discussed material in arthroplasty.

Publication types

  • Review

MeSH terms

  • Arthroplasty, Replacement / adverse effects*
  • Granuloma, Plasma Cell / chemically induced
  • Hip Joint / pathology
  • Hip Prosthesis / adverse effects
  • Humans
  • Lymphocytes / drug effects
  • Lymphocytes / pathology
  • Metal Nanoparticles / toxicity
  • Metals / toxicity*
  • Necrosis
  • Treatment Failure


  • Metals