[The effect of the oxime HI-6 on miosis induced by topical administration of sarin and VX in the rabbit eye]

Vojnosanit Pregl. 1990 Nov-Dec;47(6):399-401.
[Article in Serbian]


Effect of oxime HI-6 to rabbit miosis induced by the topical sarin and VX administration is presented. It has been found that effects of both toxins are better antagonized by parenteral than by topical HI-6 administration. The sarin antagonizing effect was found more effective. It has been also confirmed that there was no significant difference concerning the oxime HI-6 effect when topically administered either as 2.5% hypertonic or isotonic solution. Opposite to PAM-2, HI-6 effect was better in parenteral and topical administration of isotonic solutions, and less effective in local administration of hypertonic solutions.

MeSH terms

  • Animals
  • Cholinesterase Inhibitors / toxicity*
  • Cholinesterase Reactivators / administration & dosage
  • Cholinesterase Reactivators / pharmacology*
  • Miosis / chemically induced*
  • Miosis / physiopathology
  • Organothiophosphorus Compounds / toxicity*
  • Oximes / administration & dosage
  • Oximes / pharmacology
  • Pyridinium Compounds / administration & dosage
  • Pyridinium Compounds / pharmacology*
  • Rabbits
  • Sarin / toxicity*


  • Cholinesterase Inhibitors
  • Cholinesterase Reactivators
  • Organothiophosphorus Compounds
  • Oximes
  • Pyridinium Compounds
  • VX
  • Sarin
  • asoxime chloride