Circadian variations of total renin, active renin, plasma renin activity and plasma aldosterone in clinically healthy young subjects

Horm Metab Res. 1990 Dec;22(12):636-9. doi: 10.1055/s-2007-1004991.


The direct assay of total renin (TRC) and active renin concentration (ARC) is a reality due to the availability of monoclonal antibodies against human renin. Because of this, a study has been performed in order to assess the circadian rhythmicity of TRC and ARC. The study was extended to plasma renin activity (PRA) and plasma aldosterone concentration (PAC) for a more complete assessment of the renin-angiotensin-aldosterone system (RAAS). Twelve clinically healthy subjects (6 males and 6 females, age from 20 to 25 years) volunteered for this study. Time-qualified data series were analysed by means of chronobiological procedures in order to validate the circadian rhythm and to correlate the sinusoidal profiles. The circadian rhythm was validated at a high significance for TRC, ARC, PRA and at a borderline significance for PAC. The periodic oscillations were significantly correlated, demonstrating that TRC, ARC, PRA and PAC cycles oscillate in synchronism during the 24-hour span.

MeSH terms

  • Adult
  • Aldosterone / blood*
  • Circadian Rhythm*
  • Female
  • Humans
  • Male
  • Reference Values
  • Renin / blood*
  • Renin-Angiotensin System / physiology


  • Aldosterone
  • Renin