Monoclonal antibody Ki-67: its use in histopathology

Histopathology. 1990 Dec;17(6):489-503. doi: 10.1111/j.1365-2559.1990.tb00788.x.


Monoclonal antibody Ki-67 is a reliable and easy means of accurately assessing the growth fraction of human neoplasms. Although the number of long-term follow-up studies is limited, it does appear to provide valuable prognostic information particularly in lymphoproliferative disease. Since the estimation of growth fraction is only one factor influencing tumour behaviour it would be naive to believe that measurement of this parameter alone, no matter how accurately, would provide the clinician with definitive prognostic information for all tumours. The antibody is also of use in research, providing a means of measuring proliferative activity in a variety of conditions besides malignancy, and may prove of value in monitoring tumour response to established and trial therapies.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal
  • Antigens, Surface* / analysis
  • Biomarkers
  • Biopsy / methods
  • Breast Neoplasms / pathology
  • Cell Cycle
  • Cell Division
  • Connective Tissue Diseases / pathology
  • Humans
  • Ki-67 Antigen
  • Lymphoproliferative Disorders / pathology
  • Nutritional Physiological Phenomena


  • Antibodies, Monoclonal
  • Antigens, Surface
  • Biomarkers
  • Ki-67 Antigen