The retention signal for soluble proteins of the endoplasmic reticulum

Trends Biochem Sci. 1990 Dec;15(12):483-6. doi: 10.1016/0968-0004(90)90303-s.


The lumen of the endoplasmic reticulum (ER) contains a number of soluble proteins, many of which help the maturation of newly synthesized secretory proteins. Retention of these resident proteins in the ER is dependent on a carboxy-terminal signal, which in animal cells is usually Lys-Asp-Glu-Leu (KDEL). This signal is thought to be recognized by a membrane-bound receptor that continually retrieves the proteins from a later compartment of the secretory pathway and returns them to the ER.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Endoplasmic Reticulum / chemistry*
  • Molecular Sequence Data
  • Protein Sorting Signals / chemistry*
  • Solubility


  • Protein Sorting Signals