A convenient synthesis of 3-keto bile acids by selective oxidation of bile acids with silver carbonate-Celite

J Lipid Res. 1978 May;19(4):501-4.

Abstract

A number of 3-keto bile acids were synthesized by the selective oxidation of bile acid methyl esters with silver carbonate-Celite in refluxing toluene. The pure 3-keto bile acids were isolated simply by filtering the reaction mixture and concentrating the filtrate. The relation of the bile acid structure to the oxidation rate is also discussed.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bile Acids and Salts*
  • Indicators and Reagents
  • Ketosteroids / chemical synthesis*
  • Methods
  • Molecular Conformation
  • Silicon Dioxide
  • Silver Compounds

Substances

  • Bile Acids and Salts
  • Indicators and Reagents
  • Ketosteroids
  • Silver Compounds
  • keto bile acids
  • silver carbonate-Celite
  • Silicon Dioxide