Respiratory deterioration during growth hormone therapy in a case of congenital nemaline myopathy

Eur J Pediatr. 1990 Nov;150(1):69-71. doi: 10.1007/BF01959486.


Congenital nemaline myopathy (CNM) is generally classified as a non-progressive or slowly progressive neuromuscular disease. We describe a boy with CNM and an isolated partial growth hormone (GH) deficiency. From the onset of GH therapy his respiratory capacity deteriorated rapidly. The possible association between this deterioration and GH therapy is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Growth Hormone / adverse effects*
  • Growth Hormone / pharmacology
  • Humans
  • Hypoventilation / chemically induced*
  • Hypoventilation / etiology
  • Male
  • Muscles / drug effects
  • Neuromuscular Diseases / complications
  • Neuromuscular Diseases / congenital*
  • Respiratory Insufficiency / chemically induced
  • Respiratory Insufficiency / etiology
  • Scoliosis / complications


  • Growth Hormone