MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting

J Am Chem Soc. 2010 Sep 22;132(37):12829-31. doi: 10.1021/ja105563a.


The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Anthracenes / chemistry*
  • Cell Line, Tumor
  • Gadolinium / chemistry*
  • Humans
  • Magnetic Resonance Imaging*
  • Mice
  • Mice, Nude
  • Molecular Weight
  • Peptoids / chemistry*
  • Peptoids / metabolism*
  • Vascular Endothelial Growth Factor Receptor-2 / metabolism*


  • Anthracenes
  • Peptoids
  • dendron
  • Gadolinium
  • Vascular Endothelial Growth Factor Receptor-2