Premarital screening test results for β-thalassemia and sickle cell anemia trait in east Mediterranean region of Turkey

Pediatr Hematol Oncol. 2010 Nov;27(8):608-13. doi: 10.3109/08880018.2010.503772.


Hemoglobinopathies are common diseases in Mediterranean region of Turkey. In this study, the results of a 3-year premarital screening program are reported in Kahramanmaras province, which is located in East Mediterranean region. A total of 48,126 persons were screened in this program. Hematological analyses and electrophoresis were done to identify carriers. The prevalence of β-thalassemia trait and of sickle cell anemia trait, which were 2.1% and 0.5% in Turkey, were found to be 2.8% and 0.4%, respectively, in our study. Of the carriers of the β-thalassemia trait, 82% had high hemoglobin A₂, 34% had high hemoglobin F, and 18% had both high hemoglobin F and hemoglobin A₂. β-Thalassemia trait in Kahramanmaras is slightly higher than the average rate in Turkey. However, sickle cell anemia trait is similar to Turkey's averages.

MeSH terms

  • Adolescent
  • Adult
  • Anemia, Sickle Cell / diagnosis*
  • Anemia, Sickle Cell / epidemiology*
  • Anemia, Sickle Cell / genetics
  • Female
  • Humans
  • Male
  • Mass Screening*
  • Mediterranean Region / epidemiology
  • Middle Aged
  • Premarital Examinations*
  • Prevalence
  • Turkey / epidemiology
  • Young Adult
  • beta-Thalassemia / diagnosis*
  • beta-Thalassemia / epidemiology*
  • beta-Thalassemia / genetics