Increased expression of peroxiredoxin 6 and cyclophilin A in squamous cell carcinoma of the tongue

Oral Dis. 2011 Apr;17(3):328-34. doi: 10.1111/j.1601-0825.2010.01730.x. Epub 2010 Aug 27.


Objectives: The aim of this study was to assess the expression levels of two proteins, such as PRDX6 and cyclophilin A (CypA), and to evaluate their relationship with clinicopathologic features and survival in tongue squamous cell carcinomas (TSCCs).

Material and methods: An immunohistochemical study was performed comprising a total of 42 tissue samples of patients suffering from TSCCs as well as 10 corresponding adjacent normal tissues. After detection of PRDX6 and CypA, their expression levels were semiquantitatively evaluated and correlated with clinicopathologic variables.

Results: Both PRDX6 and CypA expressions were significantly higher in tissue samples of TSCCs compared with the 10 corresponding adjacent normal tissues (P < 0.01). A statistically significant correlation in TSCCs regarding the expression of PRDX6 and CypA was revealed (P = 0.005), and the lymphadenectasis was correlated with PRDX6 (P < 0.05). Results of a multivariate analysis revealed age, CypA expression, cervical lymph node metastases, and tongue cancer differentiation to be independent prognostic variables in respect of the overall survival rate (P < 0.05).

Conclusions: It could be detected that PRDX6 and CypA are associated with tumorigenesis in TSCCs. High levels of CypA expression may predict reduced survival time.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / secondary
  • Cell Differentiation
  • Cell Nucleus / ultrastructure
  • Cyclophilin A / analysis*
  • Cytoplasm / ultrastructure
  • Cytosol / chemistry
  • Dilatation, Pathologic / pathology
  • Female
  • Follow-Up Studies
  • Humans
  • Lymph Nodes / pathology
  • Lymphatic Metastasis / pathology
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Peroxiredoxin VI / analysis*
  • Prognosis
  • Survival Rate
  • Tongue / pathology
  • Tongue Neoplasms / pathology*


  • Biomarkers, Tumor
  • PRDX6 protein, human
  • Peroxiredoxin VI
  • Cyclophilin A