Phosphatase activity controls the ups and downs of cerebellar learning

Neuron. 2010 Aug 26;67(4):525-6. doi: 10.1016/j.neuron.2010.08.015.


Investigations of the cellular substrate for cerebellar learning have focused largely on a single form of plasticity, kinase-dependent long-term depression (LTD). In this issue of Neuron, Schonewille et al. provide evidence that calcineurin, a protein phosphatase required for long-term potentiation (LTP) and other cellular processes, may be just as important.

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