Ultrasonography in regenerative injection (prolotherapy) using dextrose, platelet-rich plasma, and other injectants

Phys Med Rehabil Clin N Am. 2010 Aug;21(3):585-605. doi: 10.1016/j.pmr.2010.06.003.


Recent advances in ultrasound technology are leading physiatrists to new understandings of pain sources, new treatment options, and the ability to guide soft tissue interventions. This article examines the role of imaging ultrasound in diagnosing soft tissue injury and disease that may respond to regenerative medicine techniques (known as prolotherapy) using injectants such as dextrose, morrhuate sodium, or platelet-rich plasma. The current state of ultrasound evidence for these interventions is reviewed. Case examples assist in understanding clinical applications that currently outpace the evidence base. Development of quantitative ultrasound measures to objectively evaluate soft tissue organization is discussed.

Publication types

  • Review

MeSH terms

  • Glucose / administration & dosage*
  • Glucose / therapeutic use
  • Humans
  • Injections
  • Platelet-Rich Plasma*
  • Sclerosing Solutions / administration & dosage*
  • Sclerosing Solutions / therapeutic use
  • Sodium Morrhuate / administration & dosage*
  • Sodium Morrhuate / therapeutic use
  • Tendinopathy / diagnostic imaging*
  • Tendinopathy / drug therapy
  • Ultrasonography


  • Sclerosing Solutions
  • Sodium Morrhuate
  • Glucose